REM sleep atonia: responsible brain regions, quantification, and clinical implication

Muscle tone is profoundly suppressed during rapid-eye-movement sleep. Two indices that quantify this muscle activity suppression were introduced: the tonic inhibition index (TII) and the phasic inhibition index (PII). TII expresses the shortening of phasic chin muscle activity, and PII indicates the degrees of suppression of the occurrence of phasic chin muscle activity in the period of the burst of rapid eye movements. TII increased significantly with age, while PII decreased significantly. TII was found to reach the adult level at 12.3 years of age, while PII decreased to the adult value at 0.4 years. According to this difference in age between their maturation, the human nervous systems involved in muscle activity suppression are hypothesized to comprise at least two independent systems. TII and PII are also hypothesized to be affected by the activity of the brainstem inhibitory centers, which might be implicated in the suppression of muscle activity during wakefulness as well.