Electrogenerated chemiluminescence determination of cefadroxil antibiotic

The electrogenerated chemiluminescence (ECL) coupled to a flow injection analysis system was used for the determination of cefadroxil. In this study, the tris(2,2´-bipyridine)ruthenium (II) complex, whose luminescence increased with the presence of the cefadroxil was used. A linear equation between the luminescence peak intensity and the cefadroxil concentration, was obtained for deoxygenated solutions over the range of 5×10-8 to 1×10-4moll-1. No interference was observed and the luminescence method was successfully applied to the determination of cefadroxil in a commercial product, being the recoveries in the order of 100%.