Title of article :
Circulating endothelial/skeletal progenitor cells for bone regeneration and healing
Author/Authors :
Tomoyuki Matsumoto، نويسنده , , Ryosuke Kuroda، نويسنده , , Yutaka Mifune، نويسنده , , Atsuhiko Kawamoto، نويسنده , , Taro Shoji، نويسنده , , Masahiko Miwa، نويسنده , , Takayuki Asahara، نويسنده , , Masahiro Kurosaka، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
6
From page :
434
To page :
439
Abstract :
An emerging strategy in the regeneration and repair of bone is to use stem cells, including bone marrow mesenchymal stem cells, which are the most investigated and reliable source for tissue engineering, as well as circulating skeletal stem/progenitor cells, which are receiving abundant attention in regenerative medicine due to their ease of isolation and high osteogenic potential. Because failures in fracture healing are largely due to poor vascularization among many environmental factors, we highlight the first proof-of-principle experiments that elucidated the collaborative multi-lineage differentiation of circulating CD34 positive cells – a cell-enriched population of endothelial/hematopoietic progenitor cells – into not only endothelial cells but also osteoblasts. These cells develop a favorable environment for fracture healing via vasculogenesis/angiogenesis and osteogenesis, ultimately leading to functional recovery from fracture. This review will also highlight current concepts of circulating stem/progenitor cell-based therapy and their potential application for bone repair.
Keywords :
Circulating skeletal progenitor cellsEndothelial progenitor cellsBone regenerationVasculogenesis CD34+ cells
Journal title :
Bone
Serial Year :
2008
Journal title :
Bone
Record number :
496993
Link To Document :
بازگشت