Title of article :
The effect of antipsychotic medication on relative cerebral blood perfusion in schizophrenia: Assessment with technetium-99m hexamethyl-propyleneamine oxime single photon emission computed tomography
Author/Authors :
Del D. Miller، نويسنده , , Karim Rezai، نويسنده , , Randall Alliger، نويسنده , , Nancy C. Andreasen، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1997
Abstract :
Functional neuroimaging studies in schizophrenia have often been confounded by various factors including medication status. To explore the effects of antipsychotic medications on relative regional cerebral perfusion, we scanned a group of 33 persons with schizophrenia twice, while receiving a stable dose of antipsychotic and after being off antipsychotics for 3 weeks, using technetium-99m hexamethylpropyleneamine oxime single photon emission computed tomography (Tc-99m HMPAO-SPECT). We found that antipsychotics significantly increased the mean relative cerebral perfusion in the left basal ganglia. Additionally, patients receiving thiothixene (n = 9) had a significantly greater increase in relative cerebral perfusion in the basal ganglia than patients receiving haloperidol (n = 12). These findings indicate that antipsychotics lead to regional increases in cerebral perfusion and that antipsychotic status must be controlled for in functional neuroimaging studies. Functional neuroimaging techniques such as SPECT may be useful in furthering our understanding of the mechanism of antipsychotics.
Keywords :
Schizophrenia , Tc-99m HMPAO SPECT , Relative regional cerebral blood flow , Antipsychotics
Journal title :
Biological Psychiatry
Journal title :
Biological Psychiatry