Retention and Separation of Adenosine and Analogues by Affinity Chromatography with an Aptamer Stationary Phase

Advances in instrumentation used for particle composirional analysis have enabled real-time identification and classification of individual particles. However, precise quantitation of individual particle compositions has been elusive. Here, we demonstrate that real-time quantitative single-particle compositional analysis is possible. This is illustrated for individual particles of sodium chloride (70 nm), ammonium sulfate (70 nm), and silica (40-2000 nm) using a real-time aerosol mass spectrometer. Atomic fractions for major components (> 1% concentration) of individual multicomponent particles have been measured within ±20%) accuracy. Trace element detection limits of 20 ppm are also demonstrated when individual particle compositions are ensemble averaged.