Simple purification of recovered [18O]H2O by UV, ozone, and solid-phase extraction methods

We have developed three methods for removing organic impurities as well as a solid-phase extraction (SPE) method for removing metallic and ionic impurities from recovered [18O]H2O. Preliminary experiments with [16O]H2O were used to determine the optimal purification conditions. These showed that UV irradiation rapidly (<4 h) eliminated low boiling point impurities such as acetonitrile and acetone with only a slight loss of mass. A combination of UV irradiation and purging with ozone removed high boiling point impurities such as ethanol and methanol more quickly than UV irradiation alone. UV irradiation followed by a SPE with [18O]H2O removed all organic and inorganic impurities. The purified [18O]H2O gave a saturation yield of 128.62±15.6 mCi/μA for [18F]fluoride and a 49.8±12.7% radiochemical yield for [18F]fluorodeoxyglucose.