Title of article :
The GNB3 C825T polymorphism affects response to HCV therapy with pegylated interferon in HCV/HIV co-infected but not in HCV mono-infected patients
Author/Authors :
Golo Ahlenstiel، نويسنده , , Hans Dieter Nischalke، نويسنده , , Karin Bueren، نويسنده , , Thomas Berg، نويسنده , , Martin Vogel، نويسنده , , Michael Biermer، نويسنده , , Frank Grünhage، نويسنده , , Tilman Sauerbruch، نويسنده , , Jürgen Rockstroh، نويسنده , , Ulrich Spengler، نويسنده , , Jacob Nattermann، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
8
From page :
348
To page :
355
Abstract :
Background/Aims Response to HCV treatment with pegylated interferon-α is variable but might at least in part depend on genetic host factors. The G protein β3 unit (GNB3) C825T polymorphism has been shown to affect treatment response in HCV mono-infection. Here, we analyzed the impact of the GNB3 genotype in the context of HCV/HIV co-infection. Methods HIV/HCV co-infected (n = 112) and HCV mono-infected patients (n = 150), receiving therapy with pegylated IFN-α/ribavirin, were enrolled into this study. Furthermore, we analyzed 220 healthy and 92 HIV mono-infected patients. GNB3 genotype was defined and correlated with respect to treatment response. Results GNB3 genotype distribution differed significantly between HIV/HCV co-infected patients and HIV-positive/HCV-negative (p = 0.0002) or healthy controls (p = 0.03). Patients with a GNB3 CC genotype had significantly lower SVR rates as compared to carriers of a non-CC genotype (52% versus 77%; p = 0.018). In a logistic regression analysis the GNB3 genotype and the HCV genotype were significantly associated with response to treatment (p = 0.018). In contrast to HIV/HCV co-infected patients, GNB3 genotype did not affect response to treatment in HCV mono-infected patients. Conclusions The GNB3 825 CC genotype is associated with poor SVR rates in HIV/HCV co-infected patients. This underlines the impact of genetic host factors for treatment response.
Keywords :
hepatitis C , HCV/HIV co-infection , GNB3 , Treatment response , polymorphism , Genetic factors , HCV
Journal title :
Journal of Hepatology
Serial Year :
2007
Journal title :
Journal of Hepatology
Record number :
581434
Link To Document :
بازگشت