Title of article :
The role of nitric oxide in the inhibition of gastric epithelial proliferation in portal hypertensive rats
Author/Authors :
Dolgor Baatar، نويسنده , , Seigo Kitano، نويسنده , , Takanori Yoshida، نويسنده , , Toshio Bandoh، نويسنده , , Koichi Ninomiya، نويسنده , , Sadaki Tsuboi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1999
Pages :
6
From page :
1099
To page :
1104
Abstract :
Background/Aim: Portal hypertension is associated with inhibition of gastric epithelial proliferation and increased gastric nitric oxide synthase activity. Whether the nitric oxide inhibits gastric epithelial proliferation is unclear. Methods: Portal vein ligation was performed to induce portal hypertension in rats. The rats were treated for 7 days with either vehicle or NG-nitro-L-arginine methyl ester (L-NAME) at 5 mg/kg or 25 mg/kg doses (gastric gavage, twice a day). Sham-operated rats treated with vehicle served as controls. Hemodynamic parameters were measured using radiolabeled microspheres in anesthetized animals. Gastric epithelial proliferation was assessed by evaluating the proliferative cell nuclear antigen labeling index. Results: The cardiac index and gastric fundic blood flow were higher, and the gastric fundic proliferative cell nuclear antigen labeling index was lower in the portal hypertensive rats than in the controls. In portal hypertensive rats, the 5 mg/kg dose of L-NAME decreased the cardiac index and increased the gastric fundic proliferative cell nuclear antigen labeling index to levels similar to those found in the controls, but did not affect gastric fundic blood flow significantly. The 25 mg/kg dose of L-NAME further decreased both the cardiac index and the gastric fundic blood flow, but did not affect the gastric proliferative cell nuclear antigen labeling index significantly. Conclusions: In portal hypertensive rats, the correction of systemic hyperdynamic circulation by NO inhibition is associated with normalization of gastric epithelial proliferation. Excessive nitric oxide may inhibit gastric epithelial proliferation in portal hypertension.
Keywords :
Gastric mucosa , nitric oxide , portal hypertension , proliferating cell nuclear antigen
Journal title :
Journal of Hepatology
Serial Year :
1999
Journal title :
Journal of Hepatology
Record number :
584545
Link To Document :
بازگشت