Title of article :
Estrogen receptors in cholangiocytes and the progression of primary biliary cirrhosis
Author/Authors :
Domenico Alvaro، نويسنده , , Pietro Invernizzi، نويسنده , , Paolo Onori، نويسنده , , Antonio Franchitto، نويسنده , , Adriano De Santis، نويسنده , , Andrea Crosignani، نويسنده , , Roberta Sferra، نويسنده , , Stefano Ginanni Corradini، نويسنده , , Maria Grazia Mancino، نويسنده , , Marco Maggioni، نويسنده , , Adolfo F. Attili، نويسنده , , Mauro Podda، نويسنده , , Eugenio Gaudio، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
8
From page :
905
To page :
912
Abstract :
Background/Aims Estrogen receptors (ER) in cholangiocytes of primary biliary cirrhosis (PBC) patients and their relationship with cell proliferation and death were evaluated. Methods Liver biopsies from PBC patients with different histological stages were investigated by immunohistochemistry for ER-α and -β, cytokeratin-19, proliferating cellular nuclear antigen (PCNA), Fas and terminal deoxynucleotide transferase end labelling (TUNEL). Normal livers and livers from primary sclerosing cholangitis and alcoholic cirrhosis were investigated as controls. Results ER-α and -β were observed in cholangiocytes of PBC patients but not in normal liver. In PBC, positivity for ER-β was high (50–65%) in all histological stages while, positivity for ER-α increased from 1% in stage I to 12% in stage III (positivity correlated and co-localized in the same cell with PCNA). In stage IV of PBC, cholangiocytes were negative for ER-α in association with a lower PCNA positivity and with maximal degree of ductopenia. ER-α positivity in cholangiocytes of PBC patients was markedly lower than primary sclerosing cholangitis and alcoholic cirrhosis. Conclusions ER are expressed in PBC and other pathologies associated with cholangiocyte proliferation but not in normal subjects. The low expression of ER-α in PBC and their disappearance in the advanced histological stages suggests that an estrogenic deficiency could favour the evolution of this disease toward ductopenia.
Journal title :
Journal of Hepatology
Serial Year :
2004
Journal title :
Journal of Hepatology
Record number :
586279
Link To Document :
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