Title of article :
A comparison of treatment strategies for hypoplastic left heart syndrome using decision analysis
Author/Authors :
Pamela C. Jenkins، نويسنده , , Michael F. Flanagan، نويسنده , , James D. Sargent، نويسنده , , Charles E. Canter، نويسنده , , Richard E. Chinnock، نويسنده , , Kathy J. Jenkins، نويسنده , , Robert N. Vincent، نويسنده , , Gerald T. O’Connor، نويسنده , , Anna N. A. Tosteson، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2001
Pages :
7
From page :
1181
To page :
1187
Abstract :
OBJECTIVES We sought to identify the optimal treatment strategy for hypoplastic left heart syndrome (HLHS). BACKGROUND Surgical treatment of HLHS involves either transplantation (Tx) or staged palliation of the native heart. Identifying the best treatment for HLHS requires integrating individual patient risk factors and center-specific data. METHODS Decision analysis is a modeling technique used to compare six strategies: staged surgery; Tx; stage 1 surgery as an interim to Tx; and listing for transplant for one, two, or three months before performing staged surgery if a donor is unavailable. Probabilities were derived from current literature and a dataset of 231 patients with HLHS born between 1989 and 1994. The goal was to maximize first-year survival. RESULTS If a donor is available within one month, Tx is the optimal choice, given baseline probabilities; if no donor is found by the end of one month, stage 1 surgery should be performed. When survival and organ donation probabilities were varied, staged surgery was the optimal choice for centers with organ donation rates <10% in three months and with stage 1 mortality <20%. Waiting one month on the transplant list optimized survival when the three-month organ donation rate was ≥30%. Performing stage 1 surgery before listing, or performing stage 1 surgery after an unsuccessful two- or three-month wait for transplant, were almost never optimal choices. CONCLUSIONS The best strategy for centers that treat patients with HLHS should be guided by local organ availability, stage 1 surgical mortality and patient risk factors.
Keywords :
HLHS , hypoplastic left heart syndrome , Tx , transplantation
Journal title :
JACC (Journal of the American College of Cardiology)
Serial Year :
2001
Journal title :
JACC (Journal of the American College of Cardiology)
Record number :
596848
Link To Document :
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