Lipid Exudation Following Plaque Radiotherapy for Poterior Uveal Melanoma

Purpoe To invetigate factor aociated with lipid exudation after plaque radiotherapy for uveal melanoma. Deign Retropective interventional cae erie. Method Record of 139 conecutive uveal melanoma patient treated with I-125 plaque radiotherapy were reviewed. Lipid exudation wa the major outcome meaured. Reult Lipid exudation wa detected in 19 patient (13.7%). Mean time from plaque therapy to lipid exudation wa 10 month (range, 3–23 month). Lipid exudation wa aociated with younger patient age (P = .0002), increaed low-denity lipoprotein (P = .004), decreaed high-denity lipoprotein (P = .026), increaed tumor thickne (P = .024), and exudative retinal detachment (P = .016). Patient with lipid exudation had wore viual outcome (P < .0001) and increaed neovacular glaucoma (P = .01). Concluion Lipid exudation after plaque radiotherapy for uveal melanoma i aociated with poor ocular outcome. Factor aociated with thi lipid exudation are ditinct from thoe aociated with radiation retinopathy, and they may ugget intervention to combat thi complication.