Propective Controlled tudy of Vapor Preure Tear Omolality and Tear Menicu Height in Naolacrimal Duct Obtruction

Purpoe To determine tear omolality (TO) and tear menicu height (TMH) in patient with functional (FNLDO) and primary acquired (PANDO) naolacrimal duct obtruction. Additionally, to determine the effect of ucceful dacryocytorhinotomy urgery on thee tear parameter. Deign Propective cae-controlled interventional cae erie. Method Up to 20 μl of baal tear were collected from 20 age- and gender-matched control ubject, 33 patient with FNLDO, 28 patient with PANDO, and 31 patient after ucceful dacryocytorhinotomy. TMH wa meaured with videoreflective dacryomenicometry, and TO wa meaured with vapor preure omometry. Reult Thirty-nine percent of the patient with FNLDO (13/33) elected to undergo dacryocytorhinotomy urgery, compared with 64% of the patient with PANDO (18/28; P = .09). TMH wa ignificantly higher in the dieae group (FNLDO median, 630 ± 187 μm; PANDO median, 620 ± 210 μm) compared with the control ubject (median 262 ± 50 μm; P < .01). In thoe patient who underwent urgery, TMH wa lightly higher in FNLDO than PANDO (P = .08), and TMH reduced ignificantly after urgery (P < .05). Mean TO in the control ubject wa 313 ± 17 mmol/kg, in FNLDO wa 309 ± 19 mmol/kg, and in PANDO wa 315 ± 24 mmol/kg (P > .05). TO wa imilar in thoe patient who progreed to urgery compared with the total group and wa unaffected by urgery. Concluion TO wa imilar in normal control ubject and in the watery eye group and wa unchanged after dacryocytorhinotomy urgery. Depite the lightly higher TMH in patient with FNLDO, a higher proportion of patient PANDO elected to have urgery. Relative to FNLDO, patient with PANDO who progreed to urgery had lower TMH and normal TO, which ugget that a complete lacrimal drainage obtruction induce negative feedback that reult in no reduction in TO.