Infliximab Effect Compared to Conventional Therapy in the Management of Retinal Vaculiti in Behçet Dieae Original Reearch Article

Purpoe To ae the outcome of retinal vaculiti in patient with Behçet dieae treated with infliximab compared to treatment with conventional therapy. Deign Nonrandomized, retropective comparative clinical tudy. Method Patient with Behçet dieae with all four major criteria were included in thi tudy. Patient had recurrent epiode of uveiti and retinal vaculiti. Thirty-three patient (Group 1) were treated with oral prednione, cycloporine, and azathioprine or methotrexate for a minimum period of three month. Ten patient (Group 2) who failed to repond to conventional therapy were given infliximab at a doe of 5 mg/kg in a ingle intravenou infuion on day 1 and every two week for a total of ix doe. Patient were given the ame treatment during each ubequent relape. The main outcome meaure were the number of relape, viual outcome, and ocular complication. Reult The mean follow-up period wa 36 month in Group 1 and 30 month in Group 2. The mean number of relape wa ignificantly reduced and the duration of remiion wa longer in the infliximab therapy group compared to conventional therapy group (P < .0001). The viual acuity at 24 month follow-up wa ignificantly better in patient treated with infliximab (Group 2) when compared to conventional therapy (Group 1) (P = .0059). Concluion Patient with Behçet dieae had ignificant decreae in inflammation, improvement of viual acuity, and reduced ocular complication following infliximab when compared to conventional therapy. The number of relape wa le in the infliximab treatment group than the conventional therapy group.