Higher endothelin concentrations in the fetoplacental unit of pregnant women of African ancestry

Immunoreactive endothelin was assayed in maternal and fetal biologic fluids of women of African and European ancestry with normal singleton pregnancies undergoing cesarean section at term for obstetric reasons. Endothelin concentration was found to be higher in the umbilical vein and artery blood of women of African origin. Higher production of endothelins in the fetoplacental unit may place these women at a greater risk of preeclampsia. (Am J Obstet Gynecol 1998;178:491-2.)