Author/Authors :
Khosravi، Pejman نويسنده Clinical Resident, Department of Internal Medicine, School of Medicine , Isfahan University of Medical Sciences (IUMS), Isfahan , , Shemirani، Hasan نويسنده Department of Cardiology, Faculty of Medicine, Isfahan University of Medical Sciences (IUMS), Isfahan , , Hedayatpour، Behnoud نويسنده Medicine Doctor, Isfahan , , Golabchi، Allahyar نويسنده Cardiologist, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University Of Medical Sciences, Isfahan ,
Abstract :
Objectives: Left ventricular (LV) dysfunction heart failure is one
of the causes of morbidity and mortality following ST elevation
myocardial infarction (STEMI). This study was done to determine
the clopidogrel effect in preventing reduced LV function in patients
with STEMI.
Methods: In this study, 144 patients with STEMI admitted to the
Isfahan University of Medical Sciences hospitals were followed in
two groups for one month. The case group received Clopidogrel,
300 mg, on admission and then, 75 mg daily, while the control
group received routine therapy for STEMI without Clopidogrel.
Left ventricular ejection fraction (LVEF) on the 4th day and one
month after STEMI was measured by echocardiography. The results
of LVEF were compared within and between groups.
Results: The mean LVEF in the case group on the 4th day and one
month after STEMI were 45.92 and 52.15%, respectively
(P < 0.001). The mean LVEF in the control group on 4th day and
one month after STEMI were 44.72 and 42.71%, respectively.
Conclusions: We suggest that Clopidogrel is effective in prevention
of LVEF reduction in patients with STEMI.
