Title of article :
Flaxseed on cardiovascular disease markers in healthy menopausal women: a randomized, double-blind, placebo-controlled trial
Author/Authors :
Sylvie Dodin، نويسنده , , Stephen C. Cunnane، نويسنده , , Benoît Mâsse، نويسنده , , André Lemay، نويسنده , , Hélène Jacques، نويسنده , , Genevieve Asselin، نويسنده , , Jennifer Tremblay-Mercier، نويسنده , , Isabelle Marc، نويسنده , , Benoit Lamarche PhD، نويسنده , , France Légaré، نويسنده , , Jean-Claude Forest، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
8
From page :
23
To page :
30
Abstract :
Objective Due to its high content of lignans, α-linolenic acid and fiber, flaxseed may reduce cardiovascular disease risk in humans. The present study evaluated the effect of flaxseed on markers of cardiovascular disease risk in healthy menopausal women. Methods One hundred ninety-nine women were randomly assigned to consume 40 g daily of flaxseed or wheat germ placebo for 12 mo. Fatty acids, apolipoproteins A-1 and B, lipoprotein(a), low-density lipoprotein particle size, fibrinogen, C-reactive protein, insulin, and glucose were measured at baseline and at 12 mo. Results In total 179 women were available for the intention-to-treat analysis. Flaxseed increased plasma α-linolenic (P < 0.0001), docosapentaenoic (P = 0.001), and total ω-3 fatty (P = 0.0004) acids. Differences between flaxseed and wheat germ were observed for apolipoprotein A-1 (−0.10 ± 0.26 g/L, P = 0.011) and apolipoprotein B (−0.05 ± 0.16 g/L, P = 0.047). From baseline, flaxseed raised apolipoproteins A-1 and B by 4.4% (P = 0.006) and 3% (P = 0.054), whereas wheat germ increased these apolipoproteins by 11.6% (P < 0.0001) and 7% (P = 0.0001), respectively. Both treatments increased lipoprotein(a) (P < 0.0001) and decreased low-density lipoprotein peak particle size (P < 0.0001). Conclusion In this large, long-term, placebo-controlled trial in healthy menopausal women, flaxseed increased some ω-3 fatty acids in plasma and had a limited effect on apolipoprotein metabolism.
Keywords :
flaxseed , cardiovascular disease , -3 Fatty acid , apolipoprotein , Low-density lipoprotein particle size , Menopause
Journal title :
Nutrition
Serial Year :
2008
Journal title :
Nutrition
Record number :
718764
Link To Document :
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