Title of article :
RBC NOS: regulatory mechanisms and therapeutic aspects
Author/Authors :
Burcin ?züyaman، نويسنده , , Marijke Grau، نويسنده , , Malte Kelm، نويسنده , , Marc W. Merx، نويسنده , , Petra Kleinbongard، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2008
Pages :
9
From page :
314
To page :
322
Abstract :
Nitric oxide (NO), one of the most important vascular signaling molecules, is primarily produced by endothelial NO synthase (eNOS). eNOS is tightly regulated by its substrate l-arginine, cofactors and diverse interacting proteins. Interestingly, an NO synthase (NOS) was described within red blood cells (RBC NOS), and it was recently shown to significantly contribute to the intravascular NO pool and to regulate physiologically relevant mechanisms. However, the regulatory mechanisms and clinical implications of RBC NOS are unknown. The aim of this review is to highlight intracellular RBC NOS interactions and the role of RBC NOS in RBC homeostasis. Furthermore, macro- and microvascular diseases affected by RBC-derived NO are discussed.
Journal title :
Trends in Molecular Medicine
Serial Year :
2008
Journal title :
Trends in Molecular Medicine
Record number :
784561
Link To Document :
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