Title of article
Discovery of micromolar PDE IV inhibitors that exhibit much reduced affinity for the [3H]rolipram binding site: 3-norbornyloxy-4-methoxyphenylmethylene oxindoles
Author/Authors
Hiroko Masamune، نويسنده , , John B. Cheng، نويسنده , , Kelvin Cooper، نويسنده , , James F. Eggier، نويسنده , , Anthony Marfat، نويسنده , , Sally C. Marshall، نويسنده , , John T. Shirley، نويسنده , , Jeanene E. Tickner، نويسنده , , John P. Umland، نويسنده , , Enrique Vazquez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
1965
To page
1968
Abstract
The synthesis and the in vitro properties of a novel series of potent and selective phosphodiesterase type IV (PDE IV) inhibitors is described. Despite bearing structural similarity to rolipram, several of these compounds have much reduced affinity for the [3H]rolipram binding site.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787635
Link To Document