Author/Authors :
John J. Tegeler، نويسنده , , Barbara S. Rauckman، نويسنده , , R. Richard L. Hamer، نويسنده , , Brian S. Freed، نويسنده , , Gregory H. Merriman، نويسنده , , Luther Hellyer، نويسنده , , Marie Ortega-Nanos، نويسنده , , Steven C. Bailey، نويسنده , , Ellen S. Kurtz، نويسنده ,
Abstract :
Novel aryl-fused sphingolipids, in which aryl-/heteroaryl-moieties were incorporated into the allylic 4,5,6-positions of sphingosine, were prepared and found to possess good in vitro PKC inhibitory activity. (3-(1-Dodecynyl)phenyl)- and (4- and (5-(1-dodecynyl)-2-thienyl)-2-amino-1,3-propanediols were found to have topical antiinflammatory activity comparable to sphingosine.
