New synthesis of L-m-sarcolysin and tritiated sarcolysin

L-m-sarcolysin, L-3-[bis(2-chloroethyl) amino]-L-phenylalanine was synthesized by converting 3-nitro-L-tyrosine to L-N-acetyl-3-aminophenyl-alanine Me-ester which was hydroxyethylated and converted into the N-mustard with mesyl chloride and LiCl; the title compound was obtained by hydrolysis of the protecting groups. The tritiated compound was specifically labeled on the benzyl group.