Title of article :
Synthesis and immunosuppressive activity of ruthenium complexes
Author/Authors :
Cecilia M. Bastos، نويسنده , , Kristin A. Gordon، نويسنده , , Timothy D. Ocain، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
The syntheses and immunosuppressive activity of ruthenium complexes are described. One of the complexes (1a) was shown to be a potent inhibitor of human T-lymphocyte proliferation with an IC50 of 5 nM. The activity of these complexes compares favorably to the well known immunosuppressants Cyclosporin A and Rapamycin.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters