Title of article
New taxanes as highly efficient reversal agents for multi-drug resistance in cancer cells
Author/Authors
Iwao Ojima، نويسنده , , Pierre-Yves Bounaud، نويسنده , , Craig Takeuchi، نويسنده , , Paula Pera، نويسنده , , Ralph J. Bernacki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
189
To page
194
Abstract
New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity ( 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789205
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