Title of article
New tetrahydronaphthalene derivatives as combined thromboxane receptor antagonists and thromboxane synthase inhibitors
Author/Authors
Bernard Cimetière، نويسنده , , Thierry Dubuffet، نويسنده , , Caroline Landras، نويسنده , , Jean-Jacques Descombes، نويسنده , , Serge Simonet، نويسنده , , Tony J. Verbeuren، نويسنده , , Gilbert Lavielle، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1998
Pages
6
From page
1381
To page
1386
Abstract
A pyridine group was linked to the tetrahydronaphthalene moiety of the derivatives described in the preceding paper, to afford new combined thromboxane receptor (TP-receptor) antagonists and synthase inhibitors. The most interesting compound inhibits TXA2 synthase with an IC50 value of 0.64 μM and the aggregation of human platelets with an IC50 value of 0.063 μM and shows a long duration of action in different species after oral administration.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1998
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
789438
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