Title of article :
Molecular lipophilicity potential by clip, a reliable tool for the description of the 3D distribution of lipophilicity: Application to 3-phenyloxazolidin-2-one, a prototype series of reversible MAOA inhibitors
Author/Authors :
F. Ooms، نويسنده , , J. Wouters، نويسنده , , S. Collin، نويسنده , , F. Durant، نويسنده , , S. Jegham، نويسنده , , P. George، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1998
Abstract :
The capacity factor of eleven derivatives belonging to a prototype series of 3-phenyloxazolidin-2-one, reversible MAO inhibitors, was measured and compared to the calculated log Pcalc using the CLIP package. We demonstrate that this Molecular Lipophilicity Potential (MLP) approach is a valuable tool to estimate log Pcalc of such compounds.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters