Simplification of adenophostin A defines a minimal structure for potent glucopyranoside-based mimics of 1,4,5-trisphosphate

The synthesis of 3,4,3′-trisphosphate (7), a novel Ca2+ mobilising agonist at the Ins(1,4,5)P3 receptor, designed by excision of two motifs of adenophostin A is reported, defining a potential minimal structure for potent glucopyranoside-based agonists of Ins(1,4,5)P3 receptors.