Author/Authors :
James P. Beck، نويسنده , , Argyrios G. Arvanitis، نويسنده , , Matt A. Curry، نويسنده , , Joseph T. Rescinito، نويسنده , , Larry W. Fitzgerald، نويسنده , , Paul J. Gilligan، نويسنده , , Robert Zaczek، نويسنده , , George L. Trainor، نويسنده ,
Abstract :
A series of purin-8-ones was prepared and discovered to have excellent binding affintity to the CRH-R1 receptor. Structure-activity studies focused on amine side-chain optimization, urea substitution and pyridyl isostere incorporation. Thus, the highly potent purin-8-ones show promise as a new class of potential anxiolytics and/or antidepressants.
