Author/Authors :
Julio C. Medina، نويسنده , , Daniel Roche، نويسنده , , Bei Shan and Nigel P.C. Walker، نويسنده , , R. Marc Learned، نويسنده , , Walter P. Frankmoelle، نويسنده , , David L. Clark، نويسنده , , Terry Rosen، نويسنده , , Juan C. Jaen، نويسنده ,
Abstract :
In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of β-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution.
