Author/Authors :
Iwao Ojima، نويسنده , , Tao Wang، نويسنده , , Michael L. Miller، نويسنده , , Songnian Lin، نويسنده , , Christopher P. Borella، نويسنده , , Xudong Geng، نويسنده , , Paula Pera، نويسنده , , Rapph J. Bernacki، نويسنده ,
Abstract :
A series of second-generation taxoids bearing a substitutent on the C-2-benzoyl group and modifications at C-3′/C-10 positions was synthesized. These taxoids exhibited 2–3 orders of magnitude higher potency than that of paclitaxel against drug-resistant human breast cancer cell lines. It is also noteworthy that three taxoids showed almost no difference in activity against drug-resistant and drug-sensitive cell lines, which are categorized as “advanced second generation taxoids“.
