Title of article :
Highly versatile solid phase synthesis of biofunctional 4-aryl-3,4-dihydropyrimidines using resin-bound isothiourea building blocks and multidirectional resin cleavage
Author/Authors :
C. Oliver Kappe، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2000
Pages :
3
From page :
49
To page :
51
Abstract :
A series of pharmacologically active, functionalized 4-aryl-3,4-dihydropyrimidine-5-carboxylates (DHPMs) are prepared by a versatile novel solid phase approach. In the key step, a polymer-bound thiouronium salt is condensed with unsaturated β-ketoesters. The resulting polymer bound 1,4-dihydropyrimidines are cleaved from the resin employing multidirectional resin cleavage strategies.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2000
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
790568
Link To Document :
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