Title of article
Dibasic inhibitors of human mast cell tryptase. Part 1: Synthesis and optimization of a novel class of inhibitors
Author/Authors
Kenneth D. Rice، نويسنده , , Anthony R. Gangloff، نويسنده , , Elaine Y. -L. Kuo، نويسنده , , Jeffrey M. Dener، نويسنده , , Vivian R. Wang، نويسنده , , Robert Lum، نويسنده , , William S. Newcomb، نويسنده , , Chris Havel، نويسنده , , Daun Putnam، نويسنده , , Lynne Cregar، نويسنده , , Martin Wong، نويسنده , , Robert L. Warne، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2000
Pages
4
From page
2357
To page
2360
Abstract
The synthesis and optimization of a novel class of reversible and active-site directed dibasic inhibitors of human mast cell tryptase are described. The compounds were shown to be both remarkably potent and selective for tryptase with Ki values for optimized inhibitors in the picomolar range.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2000
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
791107
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