Author/Authors :
Mona Patel، نويسنده , , Robert J. McHugh Jr.، نويسنده , , Beverly C. Cordova، نويسنده , , Ronald M. Klabe، نويسنده , , Lee T. Bacheler، نويسنده , , Susan Erickson-Viitanen، نويسنده , , James D. Rodgers III، نويسنده ,
Abstract :
A series of 4,4-disubstituted quinolinones was prepared and evaluated as HIV-1 reverse transcriptase inhibitors. The C-3 substituted compound 9h displayed improved antiviral activity against clinically significant single (K103N) and double (K103N/L100I) mutant viruses.
