Title of article :
Synthesis of non-Natural C2-Homo-ceramide and its apoptotic activity against HL-60 cells
Author/Authors :
Keiji Shikata، نويسنده , , Hayato Niiro، نويسنده , , Hideki Azuma، نويسنده , , Taro Tachibana، نويسنده , , Kenji Ogino، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
Non-natural ceramide analogues, C2-homo-ceramide and C2-homo-dihydroceramide, were prepared from -aspartic acid via -homo-serine. The apoptotic activities of the synthesized ceramide analogues were examined in HL-60 human leukemia cells. C2-homo- and C2-bishomo-ceramide indicate low but considerable apoptotic activities in comparison with C2-ceramide.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
