Title of article :
A new synthesis of cytoxazone and its diastereomers provides key initial SAR information
Author/Authors :
Percy H. Carter، نويسنده , , Jacob R. LaPorte، نويسنده , , Peggy A. Scherle، نويسنده , , Carl P. Decicco، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
A short, enantioselective, and diastereoselective synthesis of cytoxazone, a Th2-selective immunomodulator from Streptomyces, is described. The route was readily adapted to the synthesis of the three other stereoisomers of natural cytoxazone. Evaluation of these compounds revealed that the stereochemical configuration of the oxazolidinone ring did not influence their biological activity.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters