Author/Authors :
David R. Magnin، نويسنده , , Scott A. Biller، نويسنده , , John Wetterau، نويسنده , , Jeffrey A. Robl، نويسنده , , John K. Dickson Jr.، نويسنده , , Prakash Taunk، نويسنده , , Thomas W. Harrity، نويسنده , , R. Michael Lawrence، نويسنده , , C. -Q. Sun، نويسنده , , Tammy Wang، نويسنده , , Janette Logan، نويسنده , , Olga Fryszman، نويسنده , , Fergal Connolly، نويسنده , , Kern Jolibois، نويسنده , , Lori Kunselman، نويسنده ,
Abstract :
A series of newly synthesized phosphonate esters were evaluated for their effects on microsomal triglyceride transfer protein activity (MTP). The most potent compounds were evaluated for their ability to inhibit lipoprotein secretion in HepG2 cells and to affect VLDL secretion in rats. These inhibitors were also found to lower serum cholesterol levels in a hamster model upon oral dosing.
