Title of article :
Structure–Activity relationship of benzo[b]thiophene-2-sulfonamide derivatives as novel human chymase inhibitors
Author/Authors :
Hidekazu Masaki، نويسنده , , Yusuke Mizuno، نويسنده , , Akira Tatui، نويسنده , , Akira Murakami، نويسنده , , Yuuki Koide، نويسنده , , Shoji Satoh، نويسنده , , Atsuo Takahashi، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Pages :
4
From page :
4085
To page :
4088
Abstract :
We have identified a new class of chymase inhibitor through a substituent analysis of MWP00965, which we previously discovered by in silico screening. TY-51076 (7) showed high potency (IC50=56 nM) and excellent selectivity for chymase compared to chymotrypsin and cathepsin G (>400-fold). The synthesis and structure–activity relationship of this class are described.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2003
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
793724
Link To Document :
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