Title of article :
Synthesis of new 3-Arylisoquinolinamines: effect on topoisomerase I inhibition and cytotoxicity
Author/Authors :
Won-Jea Cho، نويسنده , , Sun Young Min، نويسنده , , Thanh Nguyen Le، نويسنده , , Tae Sung Kim، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2003
Abstract :
To investigate the structure–activity relationships of 3-arylisoquinolines, diverse substituted 3-aryisoquinolinamines were synthesized and tested in vitro antitumor activity against four tumor cell lines. Some of the compounds showed potent topoisomerase I inhibitory activity. Docking study of 7d with topoisomerase I–DNA complex was also performed.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters