Title of article :
A novel series of potent and selective IKK2 inhibitors
Author/Authors :
Alistair H. Bingham، نويسنده , , Richard J. Davenport، نويسنده , , Lewis Gowers، نويسنده , , Roland L. Knight، نويسنده , , Christopher Lowe، نويسنده , , David A. Owen، نويسنده , , David M. Parry، نويسنده , , Will R. Pitt، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
4
From page :
409
To page :
412
Abstract :
A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.
Keywords :
Potent , IKK2 , Selective , Inhibitors.* Corresponding author. Tel.: +44-1223-896491 , fax: +44-1223-
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2004
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
793997
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=793997
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