Title of article
2,3-Diphenylpropionic acids as potent VLA-4 antagonists
Author/Authors
Yoichiro Hoshina، نويسنده , , Satoru Ikegami، نويسنده , , Akihiko Okuyama، نويسنده , , Hideto Fukui، نويسنده , , Kiyoshi Inoguchi، نويسنده , , Tatsuya Maruyama، نويسنده , , Kyoko Fujimoto، نويسنده , , Yuzuru Matsumura، نويسنده , , Akinori Aoyama، نويسنده , , Tatsuhiro Harada، نويسنده , , Hiroshi Tanaka ، نويسنده , , Tsutomu Nakamura، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
217
To page
220
Abstract
The discovery and SAR of 2,3-diphenylpropionic acid derivatives as highly potent VLA-4 antagonists are described. One representative compound, 9cc has inhibited intercellular adhesion by a VCAM-1/VLA-4 interaction with an IC50 of 1.7 nM, and has good pharmacokinetics and oral bioavailability.
Keywords
2 , 3-Diphenylpropionic acid , VLA-4 , VCAM-1
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795181
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