Title of article
N-Arylalkylpiperidine urea derivatives as CC chemokine receptor-3 (CCR3) antagonists
Author/Authors
Douglas G. Batt، نويسنده , , Gregory C. Houghton، نويسنده , , John Roderick، نويسنده , , Joseph B. Santella III، نويسنده , , Dean A. Wacker، نويسنده , , Patricia K. Welch، نويسنده , , Yevgeniya I. Orlovsky، نويسنده , , Eric A. Wadman، نويسنده , , James M. Trzaskos، نويسنده , , Paul Davies، نويسنده , , Carl P. Decicco، نويسنده , , Percy H. Carter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
5
From page
787
To page
791
Abstract
The synthesis and structure–activity relationships of N-arylalkylpiperidylmethyl ureas as antagonists of the CC chemokine receptor-3 (CCR3) are presented. These compounds displayed potent binding to the receptor as well as functional antagonism of eotaxin-elicited effects on eosinophils.
Keywords
piperidine , eotaxin , CCR3
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795288
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