Title of article
Synthesis of isonicotinic acid N′-arylidene-N-[2-oxo-2-(4-aryl-piperazin-1-yl)-ethyl]-hydrazides as antituberculosis agents
Author/Authors
Neelima Sinha، نويسنده , , Sanjay Jain، نويسنده , , Ajay Tilekar، نويسنده , , Ram Shankar Upadhayaya، نويسنده , , Nawal Kishore Dubey، نويسنده , , Gour Hari Jana، نويسنده , , Sudershan K. Arora، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
4
From page
1573
To page
1576
Abstract
A new series of antituberculosis agents 6–9 was designed, synthesized and evaluated for antituberculosis activity against Mycobacterium tuberculosis H37Rv and clinical isolates in an agar dilution method. Compound 9h showed comparable in vitro activity (MIC) to isoniazid against M. tuberculosis H37Rv and clinical isolates (sensitive strains) and superior activity against resistant strains of M. tuberculosis.
Keywords
synthesis , Tuberculosis , Antituberculosis activity , 2-Oxo-2-(4-aryl-piperazin-1-yl)-ethyl-substituent , Isonicotinic acid hydrazide derivatives
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795437
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