Title of article
Design and synthesis of a potent macrocyclic 1,6-napthyridine anti-human cytomegalovirus (HCMV) inhibitors
Author/Authors
Guy Falardeau، نويسنده , , Hugo Lachance، نويسنده , , Annie St-Pierre، نويسنده , , Constantin G. Yannopoulos، نويسنده , , Marc Drouin، نويسنده , , Jean Bédard، نويسنده , , Laval Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
3
From page
1693
To page
1695
Abstract
A novel class of macrocyclic 1,6-napthyridines designed to adopt the presumed bioactive conformation of anti-HCMV acyclic 1,6-napthyridines are described. Both 14- and 15-membered macrocycles were shown to be highly potent against HCMV HSV-1 and HSV-2.
Keywords
hCMV , Polycyclic heterocyclic compounds , Anti-virals , Macrocycle , Anti-proliferative agents , HSV , Naphthyridine
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2005
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
795461
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