Author/Authors :
James M. Nyangulu، نويسنده , , Samantha L. Hargreaves، نويسنده , , Susan L. Sharples، نويسنده , , Simon P. MacKay، نويسنده , , Roger D. Waigh، نويسنده , , Olivier Duval، نويسنده , , Eddie K. Mberu، نويسنده , , William M. Watkins، نويسنده ,
Abstract :
Analogues of the antimalarial alkaloid nitidine have been prepared with high potency against both chloroquine-sensitive and -resistant strains of Plasmodium falciparum in vitro. Simple modifications, using an established synthetic route, resulted in an analogue with IC50 below 5 ng/mL against a chloroquine-sensitive strain of P. falciparum. N-Ethylethoxidine had IC50 below 30 ng/mL against both chloroquine-sensitive and chloroquine-resistant strains of P. falciparum.
