Title of article :
Redox-responsive and calcium-dependent switching of glycosyldisulfide interactions with Concanavalin A
Author/Authors :
Zhichao Pei، نويسنده , , Teodor Aastrup، نويسنده , , Henrik Anderson، نويسنده , , Olof Ramstr?m، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2005
Pages :
4
From page :
2707
To page :
2710
Abstract :
Glycosyldisulfides can interact efficiently with carbohydrate-binding entities. This has been shown for a range of thiosaccharide dimers when tested for their effects against the lectin Concanavalin A using a modified quartz crystal microbalance-technique. Contrary to the thiosaccharide monomers, showing no significant binding up to 10 mM, several of the dimers showed IC50-values in the low millimolar range. Three of the glycosyldisulfides tested also displayed very high positive apparent cooperativity effects that were found to be both calcium-dependent and redox-responsive.
Keywords :
lectins , Dynamic chemistry , Molecular recognition , Quartz crystal microbalance , Thiosaccharides , Glycochemistry
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
2005
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
795654
Link To Document :
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