Author/Authors :
Chixu Chen، نويسنده , , Brian Stearns، نويسنده , , Tao Hu، نويسنده , , Naomi Anker، نويسنده , , Angelina Santini، نويسنده , , Jeannie M. Arruda، نويسنده , , Brian T. Campbell، نويسنده , , Purabi Datta، نويسنده , , Jayashree Aiyar، نويسنده , , Benitio Munoz، نويسنده ,
Abstract :
The SAR of the lead compound 3, a novel ligand for the α2δ subunit of voltage-gated calcium channels, was rapidly explored. Utilizing a parallel solution-phase Sn2Ar coupling approach, a focused library was obtained. The library was evaluated in vitro and afforded a series of analogues with improved potencies. The SAR trends of the library are also described.
