Title of article
Bis-pyridiumaldoxime reactivators connected with CH2O(CH2)nOCH2 linkers between pyridinium rings and their reactivity against VX
Author/Authors
Kyung-Ae Oh، نويسنده , , Garp Yeol Yang، نويسنده , , Daniel Jun، نويسنده , , Kamil Kuca، نويسنده , , Young-Sik Jung، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2006
Pages
4
From page
4852
To page
4855
Abstract
New bis-pyridinium oxime reactivators connected with CH2O(CH2)nOCH2 linkers between two pyridinium rings were designed and synthesized, and their reactivation potency was evaluated for AChE inhibited by organophosphorus VX agent. Among the prepared compounds, 1,2-dimethoxy-ethylene-bis-N,N′-4-pyridiumaldoxime dichloride 5a was the most potent and appeared to be the most promising compound as a potential reactivator for AChE inhibited by organophosphorus VX agent.
Keywords
Organophosphorus nerve agents , Bis-pyridiumaldoxime reactivators , Acetylcholinesterase , linker
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2006
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797293
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