Title of article
Estrogen receptor β ligands: Design and synthesis of new 2-phenyl-isoindole-1,3-diones
Author/Authors
John W. Ullrich، نويسنده , , Rayomand J. Unwalla and William S. Somers، نويسنده , , Robert R. Singhaus Jr.، نويسنده , , Heather A. Harris، نويسنده , , Richard E. Mewshaw، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
118
To page
122
Abstract
The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.
Keywords
ER? and ER? receptor , nuclear hormone receptor , estrogen receptor
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797609
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