Title of article
Synthesis and activity of quinolinyl-methylene-thiazolinones as potent and selective cyclin-dependent kinase 1 inhibitors
Author/Authors
Shaoqing Chen، نويسنده , , Li Chen، نويسنده , , Nam T. Le، نويسنده , , Chunlin Zhao، نويسنده , , Achyutharao Sidduri، نويسنده , , Jian Ping Lou، نويسنده , , Christophe Michoud، نويسنده , , Louis Portland، نويسنده , , Nicole Jackson، نويسنده , , Jinjun Liu، نويسنده , , Fred Konzelmann، نويسنده , , Feng Chi، نويسنده , , Christian Tovar، نويسنده , , Qing Xiang، نويسنده , , Yingsi Chen، نويسنده , , Wen-Yang Wen، نويسنده , , Lyubomir T. Vassilev، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2134
To page
2138
Abstract
A novel series of quinolinyl-methylene-thiazolinones has been identified as potent and selective cyclin-dependent kinase 1 (CDK1) inhibitors. Their synthesis and structure activity relationships (SAR) are described. Representative compounds from this class reversibly inhibit CDK1 activity in vitro, and block cell cycle progression in human tumor cell lines, suggesting a potential use as antitumor agents.
Keywords
Cyclin-dependent kinase , CDK1 inhibitor , anticancer
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
797997
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