Title of article
1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors
Author/Authors
Thomas Lübbers، نويسنده , , Markus B?hringer، نويسنده , , Luca Gobbi، نويسنده , , Michael Hennig، نويسنده , , Daniel Hunziker، نويسنده , , Bernd Kuhn، نويسنده , , Bernd L?ffler، نويسنده , , Patrizio Mattei، نويسنده , , Robert Narquizian، نويسنده , , Jens-Uwe Peters، نويسنده , , Yves Ruff، نويسنده , , Hans Peter Wessel، نويسنده , , Pierre Wyss، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
2966
To page
2970
Abstract
In a search for novel DPP-IV inhibitors, 2-aminobenzo[a]quinolizines were identified as submicromolar HTS hits. Due to the difficult synthetic access to this compound class, 1,3-disubstituted 4-aminopiperidines were used as model compounds for optimization. The developed synthetic methodology and the SAR could be transferred to the 2-aminobenzo[a]quinolizine series, leading to highly active DPP-IV inhibitors.
Keywords
Chemical biology , combinatorial chemistry , solid-phase synthesis , fluorescence correlation spectroscopy
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798157
Link To Document