Title of article
Synthesis and SAR studies of potent imidazopyridine anticoccidial agents
Author/Authors
Gui-Bai Liang، نويسنده , , Xiaoxia Qian، نويسنده , , Dennis Feng، نويسنده , , Michael Fisher، نويسنده , , Christine M. Brown، نويسنده , , Anne Gurnett، نويسنده , , Penny Sue Leavitt، نويسنده , , Paul A. Liberator، نويسنده , , Andrew S. Misura، نويسنده , , Tamas Tamas، نويسنده , , Dennis M. Schmatz، نويسنده , , Matthew Wyvratt، نويسنده , , Tesfaye Biftu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
3558
To page
3561
Abstract
Diaryl imidazo[1,2-a]pyridine derivatives, such as 6a and 7i, have been synthesized and found to be potent inhibitors of parasite PKG activity. The most potent compounds are the 7-isopropylaminomethyl analog 6a and 2-isopropylamino analog 7i. These compounds are also fully active in in vivo assay as anticoccidial agents at 25 ppm in feed.
Keywords
Imidazopyridine , coccidiosis , Et-PKG
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798271
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