Title of article
Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors
Author/Authors
Tomomi Noguchi-Yachide، نويسنده , , Atsushi Aoyama، نويسنده , , Makoto Makishima، نويسنده , , Hiroyuki Miyachi، نويسنده , , Yuichi Hashimoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
5
From page
3957
To page
3961
Abstract
α-Glucosidase inhibitors with a chlorinated phthalimide or a thiophthalimide skeleton, derived from thalidomide, were found to possess liver X receptor (LXR) antagonistic activity. Novel LXR antagonists with a 2′-substituted phenylphthalimide skeleton were obtained by structural development of glucosidase inhibitors derived from thalidomide.
Keywords
Phthalimide , thalidomide , Liver X receptor (LXR) , Glucosidase , Antagonist
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
2007
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
798347
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